Unravelling bio-structures and applications by high resolution spectroscopies: Microwave and Laser spectrocopies

Laser spectroscopy offers high sensitivity and selectivity, making it ideal for studying biochemical systems of medium-large size. Moreover, microwave spectroscopy provides higher resolution and direct access to molecular structure. This combined approach provides not only accurate chemical insight on conformation, structure and molecular properties, but also benchmarking standards guiding the development of theoretical calculations. In order to illustrate these possibilities, there will be presented the results on the conformational landscape of several carbohydrates, peptides and glycopeptides with different biological roles, as well as other applications of high resolution spectroscopies.