The CAB Seminar series is a weekly seminar held at the Centro de Astrobiología (CAB), CSIC-INTA, Madrid. As the CAB is a multi-disciplinary research institute, these seminars cover current research in various areas of expertise including Astrophysics, Astrochemistry and Biology and advanced instrumentation, all related under the banner of Astrobiology. The seminars are given by world experts in their respective fields. The seminars are available to the public live via a link distributed via email announcements and are recorded and published online via our dedicated YouTube channel: Youtube link (link)
This webpage is dedicated to the 2023-2024 CAB Seminar Series which covers the period of 5th October 2023 to the 28th June 2024. Seminars from previous years are listed on this page: Previous Seminars (link)
Upcoming seminars are advertised via various mailing lists on the Monday of the week of the seminar. If you would like to suggest a speaker for a future seminar or add your mailing list to receive the announcements, please contact the Seminar Comision (seminarios@cab.inta-csic.es).
The CAB Seminar commission maintains a google calendar with details on upcoming seminars which can be viewed here (https://calendar.google.com/calendar/u/0?cid=Ym0wOHJuc3FiaHByNGF1anU5ZGJpMXE5ZGNAZ3JvdXAuY2FsZW5kYXIuZ29vZ2xlLmNvbQ).
Dr. Luis Sánchez-Pulido
January 12th, 2024
Analysis of Protein Function in the Twilight Zone of Homology Detection.
The identification of both sequence and structural similarities among proteins represents a potent method for deducing functional and evolutionary connections within both known and unknown proteins. This approach can yield experimentally tractable hypotheses, contributing to an enhanced comprehension of protein functions.
Proteins containing BRICHOS domains have been implicated in an unusually broad spectrum of pathologies, including cancer, obesity, and two amyloid-like diseases. The BRICHOS domains themselves are characterized as intramolecular chaperones that actively prevent amyloid-like aggregation of the mature polypeptides within these proteins. By conducting a structural analysis that involves comparing AlphaFold models based on coevolution and considering sequence conservation, we have identified new members of this protein family in humans.