Massive stars are the stellar-size agents that have a deeper impact on their host galaxy. They emit an intense ionizing radiation field that regulates the formation of the next generation of stars and planets, they synthesize crucial elements for life such as oxygen in their interior, and they are progenitors to core-collapse supernovae and gravitational waves. In this talk I will focus on metal-poor massive stars, which shaped galaxies in the past and are essential to understand the Universe in its first 4 billion years. I will summary our group’s result on this topic, that are taking current observing facilities to their limit. Finally, I will give some prospects for the future in the context of the Extremely-large Telescope (ELT) and the recent outcome of the US Decadal Astro2020 survey.
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